Everything about Mixed Gonadal Dysgenesis totally explained
Mixed gonadal dysgenesis is a condition of unusual and asymmetrical gonadal development leading to an unassigned
sex differentiation. A number of differences have been reported in the
karyotype, most commonly a
mosaicism 45,X/ 46, XY. If
Turner syndrome is defined as a condition where one sex chromosome is absent or abnormal, mixed gonadal dysgenesis may be interpreted as a specific variation of Turner’s. The phenotypical expression may be ambiguous,
intersex, or male, or female pending the extent of the
mosaicism.
It has been pointed out that the gonads may not be symmetrical, thus the development of the
Mullerian duct and
wolffian duct may be asymmetrical, too. Because of the presence of dysgenetic gonadal tissue and Y chromosome material, there's a high risk of the development of a
gonadoblastoma, thus removal of the gonads is usually indicated.
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